This paper is concerned with the reorganization of biology at Berkeley, begun in the late 1970s and early 1980s, and now well along. Key to the initiation of change was the appointment of a Chancellor and Vice-chancellor who were committed to the changes, and the enlistment of outstanding biologists already at Berkeley to design the reform and carry it through. The paper raises the following questions: what led to the momentous changes in this leading research university; what actually happened as a result of the reform; what the key forces were that made the reform possible; and...